将DSCC1基因解码为人类癌症中的泛癌生物标志物,通过全面的多omics分析
Jingru Wang1,2, Sana Fatima Gilani3, Nazia Noor4
1Mengcheng County Hospital of Chinese Medicine China.
American journal of translational research
|April 8, 2024
概括
DNA复制和姐妹染色体凝聚性1 (DSCC1) 在,肝和肺癌中过度表达,与预后不佳相关,并影响治疗反应. 这突出了DSCC1作为这些癌症中潜在的生物标志物和治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 在乳腺癌和结直肠癌中,已知DSCC1 (DNA复制和姐妹染色体凝聚性1) 的失调.
- 它在其他癌症类型中的作用在很大程度上仍未被探索.
研究的目的:
- 研究DSCC1在瘤发生和进展中的泛癌作用.
- 探索DSCC1作为预测生物标志物和治疗点的潜力.
主要方法:
- 从TCGA和GTEx数据库对33种实体瘤的多omics数据进行了全面分析.
- 使用RNA-seq,DNA甲基化,蛋白质表达 (HPA),突变 (cBioPortal),免疫细胞透和药物敏感性分析.
- 在临床样本上使用免疫组织化学验证的结果.
主要成果:
- 在许多癌症中,DSCC1显著过度表达,特别是脏胞细胞癌 (KIRP),肝肝细胞癌 (LIHC) 和肺腺癌 (LUAD).
- 较高的DSCC1表达与KIRP,LIHC和LUAD的更差的预后,更短的存活时间和晚期瘤阶段相关.
- 观察到DSCC1的改变,促进物低甲基化和蛋白质过度表达. 它的表达与免疫细胞透有正相关,并预测了对78种抗癌治疗的反应.
- DSCC1涉及至关重要的致癌途径,并在临床样本中被验证为过度表达.
结论:
- DSCC1在KIRP,LIHC和LUAD的启动,进展和治疗反应方面发挥着关键作用.
- DSCC1 作为这些特定癌症的潜在预后生物标志物和治疗标.
- 这些发现为开发针对DSCC1.1的个性化治疗策略提供了基础.
相关概念视频
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.6K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.6K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K