降低对比度敏感性功能与简单高近视症中形光受体的变化相关
Jiefang Wang1,2,3, Xinting Liu1,2,3, Jing Huang1,2,3
1Eye Hospital and School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in neuroscience
|April 8, 2024
概括
简单的高近视 (SHM) 与对比度敏感功能 (CSF) 的降低和视网膜微观结构的改变有关. 较低的圆密度与中枢液减少相关,突出显示近视的潜在视觉路径变化.
科学领域:
- 眼科医生 眼科 眼科
- 视觉科学科学 视觉科学
- 视网膜成像 视网膜成像
背景情况:
- 对比度敏感功能 (CSF) 对于视觉表现至关重要.
- 近视,特别是简单的高近视 (SHM),可能会影响除了折射误差之外的视觉功能.
- 视网膜的早期微观结构变化可能是SHM功能缺陷的基础.
研究的目的:
- 为了研究简单高近视 (SHM) 中对比度敏感功能 (CSF) 的变化.
- 评估CSF变化与SHM视网膜微观结构早期变化之间的相关性.
- 为了比较视网膜和冠状腺的参数,分布,和 CSF 测量之间的血,低至中度近视,和SHM.
主要方法:
- 对81名受试者进行前性研究 (凝视,低/中度近视,SHM).
- 以日志性CSF曲线 (AULCSF) 下面的面积和切线空间频率 (切线SF) 测量的CSF.
- 使用适应光学 (AO) 评估视网膜微观结构,用于分析,用于视网膜层的OCTA,以及用于胸腔厚度和血管性的SS-OCT.
主要成果:
- 相比之下,SHM组的AULCSF和Cut-off SF显著降低,而血缩和低/中度近视组则显著降低.
- SHM受试者表现出较低的圆密度,较大的圆间距和较低的圆规律性.
- 在SHM中,内部/外部光受体段,RPE和胆膜厚度发生了变化;较长的轴长与中枢液和密度的降低相关.
结论:
- 简单的高近视与对比度敏感性降低有关.
- 在SHM中减少的圆密度与减少的AULCSF有显著的相关性.
- 这些发现表明,视网膜微结构变化有助于SHM的视觉缺陷.
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