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微RNA21和长非编码RNA的相互作用是癌症病理生理学的基础:叙述性综述
Roberta Giordo1, Fatemeh Abdullah M Ahmadi2, Nedal Al Husaini2
1Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.
Non-coding RNA research
|April 8, 2024
概括
非编码RNAs (ncRNAs) 调节生物过程和癌症. 涉及像MEG3这样的瘤抑制剂的miR-21和长非编码RNA (lncRNA) 轴显示出癌症诊断和治疗的潜力.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
背景情况:
- 非编码RNAs (ncRNAs) 是生物过程和疾病 (包括癌症) 的关键调节者.
- 微RNA (miRNA) 和长非编码RNA (lncRNA) 是癌症病理生理学的关键参与者.
- miR-21是一种致癌的miRNA,涉及各种癌症,促进扩散,入侵和化学抵抗.
研究的目的:
- 审查miR-21-lncRNA调节轴在癌症中的作用和影响.
- 要突出 lncRNAs 和 miR-21 在瘤发生过程中的相互作用.
- 讨论这个轴在癌症治疗中作为诊断和预后标记物的潜力.
主要方法:
- 关于癌症中ncRNA介导基因调节的最新发现的文献综述.
- 对miR-21-lncRNA相互作用的分析,包括ceRNA和miRNA海绵机制.
- 讨论与各种癌症中的miR-21相关的特定lncRNAs (MEG3,CASC2,GAS5).
主要成果:
- miR-21-lncRNA轴显著影响癌症的发生,发展和进展.
- 特定的lncRNAs (MEG3,CASC2,GAS5) 作为瘤抑制剂,通常在瘤中下调.
- 这些lncRNA与miR-21相互作用,调节致癌途径并影响瘤生长.
结论:
- miR-21-lncRNA调节网络是癌症的一个关键决定因素.
- 与miR-21相互作用的瘤抑制性lncRNAs的失调有助于瘤发生.
- 针对这一轴对新型癌症治疗策略和生物标志物具有前景.
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