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实验室测试和分析非结核性菌根菌中的耐药性

Jiao Tan¹, Yachun Wang¹, Zheng Li¹

¹Medical Laboratory, Henan Provincial Chest Hospital, Zhengzhou University, Henan Province Clinical Medical Research Center for Infectious Diseases (Tuberculosis), Zhengzhou, 450000, Henan, China.

|April 8, 2024

概括

非结核菌 (NTM) 感染通常是由缓慢生长的物种引起的,如Mycobacterium intracellulare. 观察到高耐药率,需要改善药物敏感性测试以获得有效的治疗.

科学领域:

临床微生物学临床微生物学
传染性疾病传染性疾病
诊断实验室科学诊断实验室科学

背景情况:

非结核菌 (NTM) 在临床诊断中构成了越来越大的挑战.
了解NTM的流行病学和耐药性模式对于有效的患者管理至关重要.

研究的目的:

分析NTM感染的实验室诊断结果和耐药性概况.
在特定患者队列中识别常见的NTM物种及其易感性模式.

主要方法:

在河南省胸部医院对2020-2022年NTM阳性病例的回顾性分析.
评估各种诊断方法,包括酸速涂抹,真菌菌培养,QB-SPOT和GeneXpert.
使用微板方法进行药物敏感性测试,将菌株识别作为黄金标准.

主要成果:

确定了242例NTM病例,主要是生长缓慢的真菌菌 (87.19%).
最常见的分离物是Mycobacterium intracellulare (66.53%),Mycobacterium avium (15.70%),以及Mycobacterium chelonei/abscessus (11.16%),这些分离物是最常见的.
菌根菌培养产生了最高的检测率 (87.20%),在NTM物种中观察到高耐药率.

结论:

细胞内菌菌 (Mycobacterium intracellulare) 是该地区占主导地位的NTM物种,菌菌培养是最有效的诊断测试.
NTM感染表现出显著的耐药性,突出需要进行全面的药物敏感性测试.
基于准确的敏感性测试的向组合药物治疗对于管理NTM疾病至关重要.

关键词:

药物耐药性分析分析实验室测试实验室测试实验室测试非结核性菌根菌的结核菌.具体性具体性具体性菌株鉴定菌株鉴定

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