探索眼内压力和青光眼的种族和种族差异:加拿大老龄化纵向研究
Alyssa Grant1, Marie-Hélène Roy-Gagnon1, Joseph Bastasic1
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
Heliyon
|April 8, 2024
概括
自我报告的种族/种族与眼内压 (IOP) 和青光眼有关. 即使考虑到社会,行为,遗传和健康因素,这些差异仍然存在,这表明眼风险的更深层次原因.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 眼内压力 (IOP) 和青光眼在种族和种族群体之间存在差异.
- 了解导致这些差异的潜在因素对于有针对性的干预至关重要.
研究的目的:
- 调查自我报告的种族/种族与眼内压 (IOP) 和青光眼之间的关联.
- 探索社会,行为,遗传或健康差异是否解释了这些关联.
主要方法:
- 来自加拿大长度研究老龄化综合队列的30,097名成年人的横截面分析.
- 测量了角膜补偿的IOP,并收集了自我报告的青光眼诊断和眼睛护理使用情况.
- 计算了玻璃眼多基因风险评分 (PRS),并采用了逻辑和线性回归模型.
主要成果:
- 与白人相比,黑人个体的平均内血压更高 (β = 1.46) 并且患青光眼的几率增加 (OR = 2.43).
- 与白人相比,中国,日本,韩国,东南亚和菲律宾的个人平均内血压较低.
- 对社会人口统计学,行为,遗传和健康变量的调整并没有完全解释这些观察到的种族/民族差异.
结论:
- 在IOP和青光眼患病率方面发现了显著的种族和种族差异.
- 社会人口统计学,行为,遗传和健康因素并不能完全解释这些差异.
- 需要进行进一步的纵向研究,以阐明这些差异背后的机制及其对青光眼病原体的影响.
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