Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
Autoimmune Disorders01:29

Autoimmune Disorders

421
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
421
Causality in Epidemiology01:21

Causality in Epidemiology

400
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
400

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

LKB1 attenuates the transport activity of GLUT1 by regulating the alternative splicing of PKM1/PKM2 in cervical cancer.

Journal of gynecologic oncology·2026
Same author

Essential role of the D domain of linc000889 in inhibiting avian reovirus replication.

Poultry science·2026
Same author

Precision-Engineered PROTACs: Integrating Physical and Chemical Strategies for Targeted Cancer Therapy.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The splicing factor hnRNPA1 promotes osimertinib resistance in lung adenocarcinoma by regulating NEDD4L alternative splicing.

Oncogene·2026
Same author

Tandem Mn─O─Fe Orbital Hybridization in α-MnO<sub>2</sub> to Decouple Stability and Kinetics for High-Rate Aqueous Zinc-Ion Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The ABRE-BINDING FACTOR 4-eukaryotic translation initiation factor 2B β module mediates drought-potentiated Turnip mosaic virus susceptibility in Brassica juncea.

Plant physiology·2026
Same journal

Editorial: Association of diabetes mellitus with cognitive impairment and neurological disorders, volume II.

Frontiers in endocrinology·2026
Same journal

Free water-mediated associations among choroid plexus enlargement, white matter lesions, and cognitive performance in type 2 diabetes mellitus.

Frontiers in endocrinology·2026
Same journal

Development and validation of a uric acid-inflammation-metabolism score for predicting osteoarthritis risk: evidence from NHANES 2007-2018 and an external Chinese cohort.

Frontiers in endocrinology·2026
Same journal

Sinonasal and skull base phosphaturic mesenchymal tumours: a case series and narrative review.

Frontiers in endocrinology·2026
Same journal

The double-edged sword effect of estrogen in kidney disease and its precision modulation.

Frontiers in endocrinology·2026
Same journal

Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study.

Frontiers in endocrinology·2026
查看所有相关文章

相关实验视频

Updated: Jun 29, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K

甲状腺功能障碍和败血症之间的因果关系:一个两样本的门德尔随机化研究.

Junbin Hong1, Lian Zhang1, Yanni Lai2

  • 1The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in endocrinology
|April 8, 2024
PubMed
概括
此摘要是机器生成的。

甲状腺功能低下症与喘相关的肺炎或败血症和其他败血症有因果关系. 然而,在甲状腺功能低下症和链球菌或产后败血症之间没有发现因果关系,也没有在甲状腺功能高和任何败血症亚型之间发现因果关系.

关键词:
甲状腺功能过强症 甲状腺功能过强症甲状腺功能低下症 甲状腺功能低下症门德尔的随机化是门德尔的随机化这是一种血症.甲状腺功能障碍 甲状腺功能障碍

更多相关视频

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

830
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

相关实验视频

Last Updated: Jun 29, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

830
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

科学领域:

  • 内分泌学 在内分泌学.
  • 传染病流行病学 传染病流行病学
  • 遗传流行病学遗传流行病学

背景情况:

  • 甲状腺功能障碍 (甲状腺功能过高,甲状腺功能低下) 和败血症之间的关系仍在争论中.
  • 之前的研究已经产生了关于这种关联的有争议的发现.

研究的目的:

  • 通过使用孟德尔随机化来研究甲状腺功能障碍或甲状腺功能障碍与四种不同的败血症亚型的易感性之间的因果关系.
  • 探索甲状腺功能低下症和特定的败血症亚型之间的潜在反向因果关系.

主要方法:

  • 使用全基因组关联研究 (GWAS) 数据进行了双样本门德尔随机化 (MR) 分析.
  • 仪器变量来自大型遗传数据库.
  • 进行了敏感性分析和反向MR,以评估稳定性并排除反向因果关系.

主要成果:

  • 甲状腺功能低下症与喘相关的肺炎或败血症 (OR=1.097) 和其他败血症 (OR=1.070) 有因果关系.
  • 甲状腺功能低下症和链球菌或产后败血症之间没有发现因果关系.
  • 没有证据表明甲状腺功能障碍和任何研究的败血症亚型之间存在因果关系.

结论:

  • 甲状腺功能低下症与喘相关的肺炎或败血症和其他败血症有关.
  • 没有证据表明甲状腺功能障碍和研究的败血症亚型之间存在因果关系.
  • 这些发现有助于理解甲状腺功能和败血症风险之间的复杂相互作用.