Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hormonal Regulation01:33

Hormonal Regulation

33.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Introduction to the First Workshop on Vision Foundation Models and Generative AI for Accessibility.

... IEEE International Conference on Computer Vision workshops. IEEE International Conference on Computer Vision·2026
Same author

Structural insights into the nairovirus nucleoprotein endonuclease activity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Transition from the m Phase to o Phase in an HZO Thin Film Revealed by In Situ TEM.

Nano letters·2026
Same author

Gas Vesicles and Acoustic Protein Nanostructures in Molecular Ultrasound Nanomedicine: Translational Archetypes, Biomaterial Design, and Barriers to Clinical Realization.

International journal of nanomedicine·2026
Same author

Global and China burden of maternal sepsis and infections: a systematic global burden of disease 2021 analysis with projections to 2036.

The Journal of the Egyptian Public Health Association·2026
Same author

Highly conductive and ultrarobust elastic conductors for stretchable electronics.

Science advances·2026

相关实验视频

Updated: Jun 29, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

812

系统性炎症调节剂和妊娠前:一个双样本双向的门德尔随机化研究.

Chu Li1, Yishu Tian2, Djouhayna Dougarem3

  • 1Center for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China.

Frontiers in genetics
|April 8, 2024
PubMed
概括

这项研究调查了炎症和先兆子 (PE) 之间的遗传联系. 较高水平的瘤亡因子α (TNF-α) 和交白素-9 (IL-9) 会增加PE风险,而较低的干细胞生长因子β (SCGF-β) 和交白素-5 (IL-5) 也会增加风险.

关键词:
门德尔的随机化研究.细胞因子 细胞因子这是一种炎症炎症炎症炎症.孕前症是什么意思怀孕 怀孕 怀孕 怀孕 怀孕

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

相关实验视频

Last Updated: Jun 29, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

812
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

科学领域:

  • 遗传学 是一个遗传学.
  • 免疫学 免疫学 免疫学
  • 生殖医学 生殖医学

背景情况:

  • 系统性炎症调节剂与妊娠前 (PE) 有关,但证据仍然不一致.
  • 从动物模型和观察性研究中进行的现有研究表明,关于炎症在PE中的作用的结果是相互矛盾的.

研究的目的:

  • 使用双向门德尔随机化 (MR) 方法研究系统性炎症调节剂和孕前 (PE) 之间的因果关系.
  • 确定与患PE风险增加相关的特定炎症生物标志物.

主要方法:

  • 使用全基因组关联研究 (GWAS) 总结数据进行双向门德尔随机化 (MR) 分析.
  • 分析了两个样本:系统性炎症调节剂 (n=8,186) 和欧洲祖先的PE (n=267,242).
  • 采用逆变量加权 (IVW) 作为主要分析,使用MR-Egger,加权中位数,MR-PRESSO和Cochran的Q测试进行灵敏度和变性分析.

主要成果:

  • 瘤坏死因子α (TNF-α) 和中白素-9 (IL-9) 的升高水平与增加PE风险相关 (OR=1.32,p=0.004;OR=1.28,p=0.033).
  • 较低的干细胞生长因子β (SCGF-β) 和白蛋白-5 (IL-5) 水平与更高的PE风险相关 (OR=0.89,p=0.027;OR=0.80,p=0.030).
  • 巨细胞迁移抑制因子 (MIF) 被确定为PE的下游炎症调节剂.

结论:

  • 特定的炎症标志物,包括SCGF-β,IL-5,IL-9和TNF-α,似乎对PE风险产生因果影响.
  • PE与MIF有因果关系,表明其作为下游监管机构的作用.
  • 需要进一步的研究来验证这些生物标志物在PE管理中的潜在用途.