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三年回顾分析:营养和免疫学指数是否预测了直肠切除后的术后并发症?
Rajeevan Philip Sridhar1, Rajat Raghunath1, Mark Ranjan Jesudason1
1General and Colorectal Surgery, Christian Medical College and Hospital, Vellore, IND.
Cureus
|April 8, 2024
概括
营养和免疫学指数,如PNI,NLR和PLR不是可靠的预测器,直肠癌手术后的术后并发症. 需要进一步的研究来澄清它们在患者结果中的作用.
科学领域:
- 在瘤学瘤学.
- 外科胃肠道外科手术
- 免疫学 免疫学 免疫学
背景情况:
- 营养和免疫学指数,包括预后营养指数 (PNI),中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR),已经显示出对某些癌症的结果的预测价值.
- 它们在预测直肠癌切除后的术后并发症方面的实用性尚不清楚,现有文献中报道的截止值和测试时间不一致.
研究的目的:
- 评估PNI,NLR和PLR对接受癌症直肠切除的患者术后并发症的预测能力.
- 为了解决这些指数所确定的截止值和测试方法的变化.
主要方法:
- 在2018年4月至2021年3月期间,连续接受了为直肠癌进行直肠切除的患者的回顾性分析.
- 从血液测试中计算手术前的PNI,NLR和PLR.
- 在手术后30天内评估所有疾病和死亡率.
主要成果:
- 总共分析了199名患者. 严重发病率 (Clavien-Dindo 3-5级) 在13.6%的患者中发生,死亡率为1.
- 在有并发症和没有并发症的患者之间,没有观察到平均PNI或NLR的统计学上显著差异.
- 虽然平均PLR在两组之间显示出显著差异 (p=0.01),但仅考虑主要并发症时,这种意义就消失了.
结论:
- 该研究发现,PNI,NLR和PLR不是在直肠癌切除中术后并发症的有效预测指标.
- 这些营养和免疫指数在预测直肠手术后术后发病率方面的作用似乎有限.
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