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上消化管和消化管运动病理在逆行性喉功能障碍的尺度学上
Andrew Yousef1, Amanda Krause2, Rena Yadlapati2
1Department of Otolaryngology, University of California San Diego, La Jolla, California, USA.
概括
逆行性喉功能障碍 (RCPD) 与更长的食道上 (UES) 和更高的UES压力有关. 与对照组相比,患有RCPD的患者也表现出更不有效的吞和不完全的玻尿酸清除.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 吞障碍 吞障碍 吞障碍
背景情况:
- 逆行式喉功能障碍 (RCPD) 是一种鲜为人知的疾病.
- 有限的数据存在于RCPD的测量结果和潜在机制.
研究的目的:
- 将RCPD患者的食道生理发现与无症状队列进行比较.
- 为了阐明与RCPD相关的测量力特征.
主要方法:
- 在一家三级医疗中心进行了一项病例控制研究.
- 在手术前对13名RCPD患者和26名年龄和性别匹配的无症状对照进行了食道高分辨率阻抗计.
- 在RCPD小组中评估了对cricopharyngeal botulinum注射的治疗反应.
主要成果:
- 与对照组相比,RCPD队列的上食道关节 (UES) 长度显著更长 (4.5厘米 vs 3.7厘米) 和更高的UES基底压力 (91.9毫米升 vs 49.7毫米升).
- 在RCPD患者中,无效吞率 (70.0%与15.4%) 和不完整玻尿酸清除率 (81%与21.8%) 较高.
- 所有接受肉注射治疗的RCPD患者最初情况改善,3人需要重复干预.
结论:
- RCPD与明显的尺度发现有关,包括更长的UES,升高的UES基底压力和食道运动障碍.
- 这项研究通过比较手术前测量数据与无症状组,为RCPD的病理生理学提供了新的见解.
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