早期的听觉处理异常改变了个人的学习轨迹和对精神分裂症计算机认知训练的敏感性
Juan L Molina1,2, Yash B Joshi1,2, John A Nungaray1
1Department of Psychiatry, University of California, San Diego, CA, USA.
Psychological medicine
|April 8, 2024
概括
针对性认知训练 (TCT) 提高了精神分裂症患者的听觉处理速度,最初的收益在整个30小时的实践中持续下去. 这表明TCT学习指标可以预测治疗效益.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 听觉系统的可塑性是精神分裂症 (SZ) 干预的关键目标.
- 基于听觉的有针对性的认知训练 (TCT) 增强了听觉处理,但其学习动态是未知的.
研究的目的:
- 在SZ患者中研究TCT的学习动态.
- 评估TCT对神经认知功能和治疗结果的影响.
主要方法:
- 40名受试者 (21名SZ,19名健康) 进行了听觉处理速度 (APS) 评估.
- SZ患者完成了1小时和30小时的TCT会议,并进行了重复评估.
主要成果:
- 与健康人群相比,SZ患者的基线APS缺乏.
- 在SZ患者中,TCT显著改善了APS,效果在1小时后强烈,持续超过30小时.
- 基线APS与SZ患者30小时TCT后的口头学习收益相关.
结论:
- TCT学习指标可以预测SZ的治疗反应.
- 进一步的研究可以开发算法来优化TCT以改善临床结果.
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