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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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一个药丸可以杀死神话

Milton Tenenbein1

  • 1From the Pediatrics and Child Health, Emergency Medicine and Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba Canada.

Pediatric emergency care
|April 8, 2024
PubMed
概括

"一个药丸可以杀死"的模因对幼儿来说是不准确的,因为全米缩放显示大多数药物在单剂量中不会致命,除了阿片类药物. 这种有缺陷的概念导致对儿童不必要的紧急护理.

科学领域:

  • 儿科药理学 儿科药理学
  • 毒理学 毒理学 毒理学
  • 公共卫生信息 公共卫生信息

背景情况:

  • 自20世纪90年代以来普遍存在的"一片药丸可以杀死"迷思表明,单一的药物剂量可以对幼儿致命.
  • 这个概念被广泛传播,影响了家长的担忧,并可能导致过度管理儿科摄入.

研究的目的:

  • 在儿科毒理学中批判性地评估"一片药可以杀死"构造的科学有效性.
  • 评估这种构造对中毒中心转诊和紧急医疗服务管理的影响.
  • 为理解儿科药物风险提出一个更准确的框架.

主要方法:

  • 对儿科药理学原则的审查,特别是全米缩放.
  • 在文献中搜索婴儿 (不包括阿片类药物) 单片药片死亡的记录病例.
  • 对中毒控制中心数据和急诊室管理趋势的分析,涉及涉嫌单片药丸摄入的情况.

主要成果:

  • 全度尺度测量表明,单一的药物剂量很少对幼儿致命,阿片类药物是一个显著的例外.
  • 文献提供了极少的证据支持非阿片类药物的"一粒药丸可以杀死"的说法.
  • "一片药可以杀死"的构造导致过度转诊,长时间的紧急观察和不必要的住院治疗.

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结论:

  • "一粒药丸可以杀死"迷思是一个科学上有缺陷的概念,误解了儿科药品的风险.
  • 一个修订后的理解,承认单次非阿片类药物剂量通常不会对幼儿致命,是合理的.
  • 准确的风险沟通对于防止过度治疗和减少医疗保健系统负担至关重要.