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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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相关实验视频

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在儿科炎症性肠病中的眼内皮功能障碍.

Giovanni Di Nardo1, Mariachiara Di Pippo2, Letizia Zenzeri1,3

  • 1Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Pediatric Unit, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.

Journal of pediatric gastroenterology and nutrition
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概括

光学连贯性断层扫描血管学 (OCTA) 显示,在患有炎症性肠病 (IBD) 的儿科患者中,眼部微血管结构发生了明显的变化. 这些发现表明IBD儿童的潜在系统内皮功能障碍.

关键词:
IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD眼睛的微血管系统.光学连贯性断层扫描血管图谱儿科患者的儿童患者.

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科学领域:

  • 眼科医生 眼科 眼科
  • 儿科胃肠病学 儿科胃肠病学
  • 血管生物学 血管生物学

背景情况:

  • 炎症性肠病 (IBD) 是一种影响胃肠道的慢性疾病.
  • 眼部表现可能发生在IBD中,但小血管变化在儿科群体中没有很好的特征.
  • 光学连贯断层扫描血管学 (OCTA) 提供了一种非侵入性方法来评估眼部微血管.

研究的目的:

  • 在被诊断患有IBD的儿科患者中调查眼部微血管结构的改变.
  • 将这些变化与健康儿童的对照组中的变化进行比较.
  • 探索眼部微血管变化与儿科IBD系统内皮功能之间的潜在联系.

主要方法:

  • 招募了一组患有IBD的儿科患者 (6-18岁) 和年龄匹配的对照.
  • 对所有参与者收集了临床数据,疾病活动指数和实验室标记.
  • 进行光学连贯性断层扫描血管造影 (OCTA),以分析眼部微血管,特别是胸腔区域.

主要成果:

  • 这项研究包括63名儿童 (38名IBD,25名对照).
  • 在IBD和对照组之间观察到胸腔体光面积和胸腔体总面积的显著差异.
  • 大多数IBD患者呈现轻度至中度的疾病活性或在评估时处于缓解期.

结论:

  • 患有IBD的儿科患者表现出明显的眼睛微血管结构变化,可通过OCTA检测到.
  • 这些发现表明,与儿童IBD相关的潜在系统内皮功能障碍.
  • 在儿童IBD中,OCTA是评估微血管变化和潜在的全身并发症的宝贵工具.