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在患有高心血管风险的患者中,Olezarsen用于过高甘油三血症

Brian A Bergmark1, Nicholas A Marston1, Thomas A Prohaska1

  • 1From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.).

The New England journal of medicine
|April 8, 2024
PubMed
概括

在患有高甘油三血症的患者中,Olezarsen有效降低了甘油三和阿波利波蛋白C-III水平. 这项研究表明,显著降低甘油三,没有重大安全问题,解决未满足的临床需求.

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