在六种个人护理产品分类中对有机添加剂的目标和嫌疑人查使用液体染色学-高分辨率质谱仪
Kailin Shen1, Daeho Kang1, Younghun Choi2
1Department of Environmental Engineering, Changwon National University, Changwon, Gyeongsangnamdo 51140, Korea.
Journal of the American Society for Mass Spectrometry
|April 8, 2024
概括
这项研究优化了一种检测个人护理产品 (PCP) 中有机添加剂的方法. 甲基帕拉本是一种内分泌干扰剂,在面部清洁剂中发现高水平,突出显示了常见产品的潜在风险.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 消费者产品安全 产品安全
背景情况:
- 个人护理产品 (PCP) 含有许多化学物质,包括防腐剂和增塑剂,引发了对潜在健康影响的担忧.
- 优化分析方法对于准确识别和量化PCP等复杂矩阵中的这些添加剂至关重要.
研究的目的:
- 开发和验证一种优化的方法来对PCP中普遍存在的有机添加剂进行目标和可疑查,使用液体染色学高分辨率质谱法 (LC-HRMS).
- 评估商用PCP中9种目标有机添加剂的存在和含量.
主要方法:
- 总共有50个销量很高的PCP被用LC-HRMS分析,后用甲基三乙烯和异醇进行两步提取.
- 方法验证包括评估线性 (R2 > 0.999),检测极限 (2.5100.0 ng/g),量化极限和恢复率 (61134%).
- 目标查发现了九种化合物中的五种,而可疑查发现了248种潜在的添加剂,其中9种已初步确定,3种已确认.
主要成果:
- 在分析的PCP中检测到五种标有机添加剂.
- 甲基,一种内分泌干扰化学物质,在面部清洁剂中被发现度最高 (7860毫克/千克).
- 确认了三种可疑添加剂 (置信级别1),并暂定确定了六种 (置信级别2).
结论:
- 优化的两步提取和LC-HRMS方法对于PCP中各种有机添加剂的同时分析是有效的.
- 高度的甲基帕拉本的存在强调了对个人护理产品化学安全的持续监测的必要性.
- 该研究成功识别并初步确定了许多有机添加剂,有助于更好地了解它们在消费品中的存在.
更多相关视频
11:00Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS
Published on: May 20, 2013
22.5K
10:13Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
Published on: November 8, 2024
2.2K
相关概念视频
01:15High-Performance Liquid Chromatography: Types of Detectors
542
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
542
01:21Mass Spectrometry: Complex Analysis
763
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
763