诺杜西克拉米德A1-A4,B1和B2来自菌Nodularia sp. 的 这就是NIES-358585的标准
Journal of natural products
|April 8, 2024
概括
研究人员从培养的Nodularia sp.中发现了六种新的循环脂,noduciclamides,从培养的Nodularia sp.中. 一种化合物,noducyclamide B1,对乳腺癌细胞表现出显著的细胞毒性活性.
科学领域:
- 海洋天然产品 化学 化学
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 培养的蓝藻细菌,如Nodularia sp.,是新型生物活性化合物的来源.
- 循环脂代表了一类多样化的自然产品,具有各种生物活性.
研究的目的:
- 从培养的Nodularia sp.的水友分数中分离和表征新的循环脂. (NIES-3585).这是一个很大的问题.
- 评估针对癌症细胞系的分离化合物的细胞毒性潜力.
主要方法:
- 涉及提取和分离水友成分的化学研究.
- 使用高分辨率质谱法 (HRMS) 和1D/2D核磁共振 (NMR) 谱法阐明结构.
- 通过酸水解和先进的马菲分析来确定绝对配置.
主要成果:
- 确定了6种新的循环脂,即A1-A4 (1-4) 和B1-B2 (5-6) 结核糖胺.
- 这些脂含有非蛋白质原性氨基酸 (3-基瓦林,3-基氨酸) 和β-氨基酸酸残留物.
- 诺杜西克胺B1 (5) 对MCF7乳腺癌细胞表现出显著的细胞毒性活性 (IC50=3.0μg/mL).
结论:
- 这项研究扩大了Nodularia衍生周期性脂的已知化学多样性.
- 诺杜西克拉米德B1显示出作为乳腺癌治疗的潜在化合物的前景.
- 需要进一步研究结构-活动关系和作用机制.
相关概念视频
Nomenclature of Primary Amines
Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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