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Updated: Jun 29, 2025

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新型WRN酶抑制剂选择性地向微卫星-不稳定的癌细胞

Gabriele Picco1, Yanhua Rao2, Angham Al Saedi1

  • 1Wellcome Sanger Institute, Cambridge, UK.

Cancer discovery
|April 8, 2024
PubMed
概括

新的WRN螺旋酶抑制剂在治疗微卫星不稳定 (MSI) 癌症方面表现有前途. 这些向药物利用MSI瘤的漏洞,导致DNA损伤,并在临床前模型中抑制癌症生长.

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