在接受心脏手术的患者中,局部与静脉注射的松酸:DEPOSITION随机对照试验
André Lamy1,2, Dmitry A Sirota3, Frederic Jacques4
1Population Health Research Institute, Hamilton, ON, Canada (A.L., E.P.B-C., R.P.W., I.C., J.V., R.K., K.B., S.I.B., M.H.M., J.S., S.Y., P.J.D.).
Circulation
|April 8, 2024
概括
在心脏手术中局部使用的酸并没有降低发作风险,也没有增加输血率. 这项研究发现,与静脉注射相比,局部使用的松酸导致红细胞输血的绝对增加8. 3%.
科学领域:
- 心脏病学
- 麻醉学
- 药理学
背景情况:
- 在心脏外科手术中,静脉注射松酸是减少出血的标准.
- 通过降低血度和潜在降低发作风险,局部使用的松酸可能提供更安全的替代品.
研究的目的:
- 评估局部使用的松酸是否能减少心脏手术患者的住院发作.
- 与静脉注射相比,确定局部使用的松酸是否增加了输血的需要.
主要方法:
- 这是一项多中心,双盲,随机对照试验,涉及3242名心脏手术患者.
- 患者接受了静脉注射或局部注射的松酸.
- 由于数据和安全监测委员会发现的安全问题,该试验提前结束.
主要成果:
- 在局部治疗组中发生0. 2%的住院发作,而静脉注射组中为0. 7% (P=0. 07).
- 与静脉注射组相比,局部输血红细胞增加了8. 3% (P=0. 007).
- 在局部治疗组中,更高比例的患者接受了≥4个红细胞单位.
结论:
- 在心脏手术患者中,局部使用的酸并没有显著降低发作的发生率.
- 局部使用的松酸与红细胞输血需求的显著增加有关.
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