在头部和部外科瘤病房爆发了Streptococcus pyogenes emm89 ST646的疫情
Brian Hayama1,2, Sohei Harada1,3, Masahiro Suzuki4
1Department of Infectious Diseases, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Microbiology spectrum
|April 8, 2024
概括
在头癌患者中发生了高病毒性Streptococcus pyogenes emm89/clade 3的医院爆发. 全基因组测序证实了克隆性传播,突出了脆弱人群中这种疫情的风险.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 杆菌 pyogenes 导致人类感染和医院爆发.
- 像emm1这样的高毒性克隆在全球重新出现,改变了S. pyogenes的流行病学.
- 这种emm89/clade 3克隆的全球流行率正在上升,其病毒性与emm1.1相似.
研究的目的:
- 描述S. pyogenes爆发的临床和分子特征.
- 调查一场涉及15名患者和4名医疗保健工作者 (HCW) 的疫情.
- 分析致病性S. pyogenes分离物的传播动态和毒性.
主要方法:
- 医疗记录中的临床数据的回顾性审查.
- 16个S. pyogenes分离物的全基因组测序 (14名患者,2名HCW).
- 对单核酸多态 (SNP) 差异的分析,以评估克隆性传播.
主要成果:
- 疫情涉及15名手术后头癌患者,其中12名患有侵入性感染.
- 所有分离物属于高病毒性emm89/clade 3克隆 (ST646),SNP差异为0-1,表明克隆传播.
- 在实证抗菌药物管理实施后大约2个月内,疫情得到控制.
结论:
- 这项研究表明,在高风险患者群体中出现了S. pyogenes emm89/clade 3的爆发.
- 全球出现的高病毒性S. pyogenes克隆,如emm89/clade 3,增加了医院爆发的风险.
- 有效的制策略对于管理由毒性细菌菌株引起的疫情至关重要.
更多相关视频
03:22Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
Published on: March 1, 2024
421
09:25Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
Published on: August 19, 2016
11.0K
相关概念视频
01:20Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
01:23Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
01:30Tonsillitis I: Introduction
244
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
244
01:30Acute Pharyngitis
624
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
624
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.2K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.2K
01:22Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K