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由于类固醇单一治疗引起的C型肝炎病毒的重新激活,用于突然失聪
Hiroki Kaneko1, Yoshinori Ozono1, Hisayoshi Iwakiri1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Clinical journal of gastroenterology
|April 8, 2024
概括
型肝炎病毒 (HCV) 再激活,在类固醇单一治疗中很少见,发生在患者治疗前尼索隆 (PSL) 治疗突然失聪后. 这一案例凸显了在使用类固醇时对HCV重新激活的警的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 型肝炎病毒 (HCV) 的重新激活通常与抗癌药物和免疫抑制剂有关.
- 在类固醇单一治疗后的重新激活很少被报告.
研究的目的:
- 报告一种罕见的类固醇单一治疗后HCV活性化病例.
- 强调在接受类固醇治疗的患者中监测HCV重新激活的重要性.
主要方法:
- 一个65岁的日本男性,有HCV感染史的案例研究.
- 在突然失聪时使用普雷迪尼索隆 (PSL).
- 监测阿氨酸转移酶 (ALT) 水平和HCV RNA病毒载量.
主要成果:
- 在PSL给药两个月后,该患者出现了ALT爆发和显著的HCVRNA水平 (6.2 log IU/mL).
- 在临床和实验室发现的基础上诊断出HCV再激活.
- 使用索福斯布维尔和莱迪帕斯维尔的治疗可以实现持续的病毒学反应.
结论:
- 即使在短期的类固醇单疗法后,HCV的重新激活也可能发生.
- 临床医生应考虑HCV复激活的风险,在给HCV感染的患者开处方PSL.
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