rutin 通过 CaR/NLRP3/NF-κB 信号通路缓解 Sjogren 综合征
Jing He1, Meimei Xu1, Suling Wu2
1Department of Rheumatology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
In vitro cellular & developmental biology. Animal
|April 8, 2024
概括
鲁丁 (Ru) 显示出在治疗Sjogren的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肖格伦综合征 (SS) 是一种自身免疫性疾病,其机制和治疗方法尚不清楚.
- 下下腺在SS中受到影响,影响唾液功能.
- 感应受体 (CaR) 与SS病变发生有关.
研究的目的:
- 为了研究 rutin (Ru) 对 Sjogren 综合征 (SS) 的治疗作用.
- 探索感应受体 (CaR) /NLRP3 / NF-κB通路在SS中的作用.
- 为了确定SS治疗的潜在治疗点.
主要方法:
- 蛋白质组学分析以确定SS小鼠下腺中的差异性蛋白质.
- 唾液分泌量 (SAS) 和唾液腺指数 (SGI) 的评估.
- 检测氧化应激,炎症性细胞因子和关键通路蛋白 (NLRP3,ASC,Caspase-1,IL-1β,p-NF-κBp65).
主要成果:
- 在SS小鼠中发现了327种差异性蛋白质,CaR显著增加.
- 鲁丁 (Ru) 改善了SGI,抑制了氧化应激,并减少了炎症性细胞因子.
- 鲁丁的有效性涉及调节CaR/NLRP3/NF-κB通路,CaR过度表达部分抵消Ru的影响.
结论:
- 鲁丁 (Ru) 通过调节CaR/NLRP3/NF-κB通路,显示出对Sjogren综合征 (SS) 的治疗潜力.
- 感应受体 (CaR) 是SS的潜在治疗标.
- 这项研究为开发新型SS治疗提供了基础.
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