患有异常性正常压力脑的患者的掌握反射
Junyan Liu1, Shigenori Kanno2, Chifumi Iseki1
1Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Journal of neurology
|April 8, 2024
概括
掌握反射在异常正常压力脑症 (iNPH) 中很常见,可以表明症状的严重程度. 手术后,这些反射通常会减少或稳定,与功能测试得分的改善相关.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
背景情况:
- 异常性正常压力脑症 (iNPH) 是一种神经疾病,其特征是步态障碍,认知能力下降和尿失禁.
- 掌握反射,一种非自愿的运动反应,在iNPH患者中曾经有过事观察到,但其患病率和临床意义尚未得到充分确立.
研究的目的:
- 确定可能患有iNPH的患者的抓住反射的流行率和强度.
- 为了评估在分流手术后掌握反应的变化.
- 评估iNPH中掌握反射和临床症状之间的相关性.
主要方法:
- 一组147名可能患有iNPH的患者使用标准化方法和四类分类来评估抓取反射的存在和强度.
- 临床评级尺度被用于评估症状严重程度及其与抓住反射的相关性.
- 在位手术后一年,72名患者的掌握反射被重新评估.
主要成果:
- 大约50.3%的iNPH患者表现出积极的掌握反射,69%的患者表现出双边的积极性.
- 掌握反射的强度与步态,认知,泌尿,运动和行为症状的严重程度显著相关.
- 经过分流手术后,72.3%的患者表现出掌握反射强度的降低或维持,这与定时上路和步道制作测试A分数的改善相关.
结论:
- 掌握反射是iNPH中非常普遍的发现,并作为症状严重程度的有价值指标.
- 掌握反射的评估可以帮助评估iNPH患者的认知,步态,尿道,运动和情绪症状.
- 手术后掌握反射强度的变化可能反映了iNPH患者的功能改善.
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