对负面影响的遗传倾向预测了COVID-19大流行期间的心理健康负担
Alicia M Schowe1,2, Malvika Godara3, Darina Czamara4
1Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany. alicia_schowe@psych.mpg.de.
概括
福利和神经病症的多基因分数在COVID-19大流行期间影响了心理健康轨迹. 然而,遗传风险对于识别一般人群中易受伤害的个体的有用性有限.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- COVID-19 疫情加剧了抑郁症和焦虑症等心理健康问题.
- 遗传因素可能会影响精神疾病风险,但它们在流行病相关的心理健康反应中的作用尚不清楚.
研究的目的:
- 调查心理健康特征的多基因分数 (PGS) 是否在COVID-19大流行期间区分性-脆弱性轨迹.
- 评估遗传倾向在心理健康应对疫情中的作用.
主要方法:
- 利用来自CovSocial项目的基因型子样本 (n=1316) 的多项式回归.
- 在2020/21年封锁期间,比较了四个已识别的弹性-脆弱性轨迹.
- 用PGS作为健康和神经病的预测指标.
主要成果:
- 幸福感的更高的PGS降低了处于更脆弱的轨迹的几率 (调整后的R平方=0.3%).
- 神经病症的较高PGS增加了处于更易受伤害的轨迹的几率 (调整后R平方=0.2%).
- 没有发现潜在的心理健康变化与PGS之间存在关联.
结论:
- 多基因分数显示在COVID-19大流行期间对心理健康的影响.
- 这种有限的解释差异表明,当前的遗传标记在识别一般人群中易受伤害的个体时的效用很低.
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