在复发性复发性多发性硬化症中认知障碍的流行:系统性审查和元分析
Wendy Wu1, Heather Francis2,3, Abbie Lucien2
1The School of Psychological Sciences, Australian Hearing Hub, Macquarie University, North Ryde, Sydney, NSW, 2109, Australia. wendy.wu@mq.edu.au.
Neuropsychology review
|April 8, 2024
概括
认知障碍影响约三分之一的成年人复发性复发性多发性硬化症 (RRMS). 建议进行早期认知测试以进行检测和支持.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
背景情况:
- 在复发性复发性多发性硬化症 (RRMS) 中,认知症状很常见.
- 在RRMS中认知障碍 (CIm) 的患病率估计有很大差异.
- 在RRMS患者中,CIm与负面的功能结果有关.
研究的目的:
- 为了确定RRMS的成年人中CIm的综合流行率.
- 为了确定温和CIM流行率的因素.
主要方法:
- 对报告RRMS中CIm流行率的研究进行系统审查和元分析.
- 搜索了Embase,Scopus,Medline和PsycINFO从创立到2023年3月的时间.
- 包括使用标准化神经心理测试来定义CIm的研究.
主要成果:
- 在5859名参与者中,CIm的综合患病率为32.5% (95%CI为29.3-36.0%).
- 更高的患病率与更长的疾病持续时间,年龄较大和更广泛的神经心理测试电池有关.
- 大约三分之一的RRMS成年人经历临床CIm.
结论:
- 大约三分之一患有RRMS的成年人经历了临床显著的认知障碍.
- 建议进行常规的认知测试,用于早期检测和干预计划.
- 识别患有CIM的个体可以指导个性化治疗和支持策略.
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