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补充维生素B5可以促进肠道发育,并改变断奶小猪的微生物
Xin Wang1, Yan Qin1, Jianzhong Li1
1Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Animal biotechnology
|April 8, 2024
概括
高维生素B5 (VB5) 水平通过增强肠道形态和有益细菌,改善了断奶小猪的肠道健康. 补充50毫克/公斤VB5对大肠,盲体和结肠产生了积极影响,促进了生长和功能.
科学领域:
- 动物科学动物科学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 肠道健康对于断奶小猪的生长和发育至关重要.
- 维生素B5 (VB5) 在新陈代谢过程中起着至关重要的作用,但其对小猪肠道功能的特定影响需要进一步研究.
研究的目的:
- 调查不同饮食维生素B5 (VB5) 水平对断奶小猪的肠道生长,形态和功能的影响.
- 评估VB5补充剂对肠道微生物群组成和短链脂肪酸 (SCFA) 概况的影响.
主要方法:
- 进行了一项为期28天的养试验,对21只断奶的小猪进行了试验,分为三组,接受不同的VB5补充水平:0 mg/kg (L-VB5),10 mg/kg (控制) 和50 mg/kg (H-VB5).
- 分析了肠道组织的形态参数 (维卢斯高度,密室深度,细胞计数),并量化了肠道微生物群和SCFA水平.
主要成果:
- 在H-VB5组中,与体重相比,大肠的重量是最高的.
- 与L-VB5.5相比,对照组和H-VB5组的阴茎的高度和的高度/密室深度显著增加.
- 在阴茎 (控制和H-VB5) 和结肠 (H-VB5) 中观察到杯状和内分泌细胞的显著增加.
- 在H-VB5组表现出更高的ki67和密室深度在阴和结肠.
- 在H-VB5组中,同黄油酸和同酸水平降低,黄油酸的下降趋势.
- 在H-VB5组中,有害细菌 (例如,克洛斯特,特里斯波细菌,链球菌) 的数量显著减少,有益细菌 (图里西细菌) 的数量显著增加.
结论:
- 服用50mg/kgVB5的食补充剂显著增强了断奶小猪的形态结构,细胞增殖,以及断奶小猪的阴茎,盲体和结肠的分化.
- 补充VB5可以积极调节肠道微生物群的组成,减少致病细菌,增加有益细菌.
- 这些发现表明,最佳的VB5水平对于改善断奶小猪的肠道健康,功能和微生物平衡至关重要,这会影响SCFA生产.
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