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精油成分与抗生素对抗多药耐药的Corynebacterium条形细菌的协同作用

Umut Yilmaz¹, Ahmet Gökhan Coşkun², Yener Özel¹

¹Faculty of Medicine, Department of Medical Microbiology, Balikesir University, Balikesir 10145, Türkiye.

Journal of applied microbiology

|April 8, 2024

概括

精油成分卡瓦克罗尔和甲与抗生素对抗多药耐药的Corynebacterium条形菌具有协同作用. 这种组合增强了抗菌活性,为抗击耐药细菌感染提供了潜在的策略.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
自然产品化学化学

背景情况:

杆菌 (Corynebacterium striatum) 是一种机会性病原体,经常表现出多种药物耐药性.
精油成分 (EOC),如卡瓦克罗尔 (CAR) 和甲 (CIN),具有已知的抗菌特性.
抗生素耐药细菌的出现需要探索新的治疗策略.

研究的目的:

评估特定EOC和常规抗生素对抗多药耐药Corynebacterium条形菌的抗菌活性.
调查CAR,CIN和各种抗生素之间的协同相互作用,以对抗Corynebacterium striatum.
确定EOC与抗生素的结合是否可以提高疗效,并可能克服耐药性机制.

主要方法:

使用微稀释方法来评估EOC和抗生素的个体抗菌活性.
查克板方法被用来确定CAR,CIN和抗生素之间的协同作用.
对50种多药耐药的Corynebacterium striatum菌株和10种选择用于协同分析的菌株进行了测试.

主要成果:

对EOCs (CAR,CIN) 和抗生素 (linezolid,vancomycin,gentamicin,ciprofloxacin,clindamycin) 单独观察到抗菌活性.
当EOC (CAR,CIN) 与抗生素结合时,检测到了协同作用的相互作用.
科里尼细菌 (Corynebacterium striatum) 菌株对万科米辛和线索利德表现出敏感性,但对珍塔米辛,青素,西普罗夫洛克萨辛和克林达米辛表现出耐药性.

结论:

范科米辛和线索立德仍然对测试的Corynebacterium条状细菌菌株有效.
当与多种抗生素相结合时,卡瓦克罗和肉甲具有显著的协同效应.
这些发现表明,结合精油成分与抗生素的潜在治疗应用,用于治疗多药耐药的Corynebacterium striatum感染.

关键词:

科里尼细菌 (Corynebacterium striatum) 是一种细菌.抗生素抗生素是一种抗生素.精油成分精油成分

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