在献血者中与SARS-CoV-2感染相关的长期症状
Melisa M Shah1, Bryan R Spencer2, Jade James-Gist1
1Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA network open
|April 8, 2024
概括
具有SARS-CoV-2感染史的个人患长期症状的可能性是超过两倍. 这项研究强调了COVID-19对持续的身体和心理健康问题的重大影响.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 急性COVID-19 (SARS-CoV-2) 感染后的长期症状是一个重大的健康问题.
- 以前的研究往往缺乏足够的对照组来区分COVID-19的影响和背景症状流行.
研究的目的:
- 在大量的献血者群体中调查长期身体和精神健康症状的流行情况.
- 通过自我报告和血清学测试,将这些症状与SARS-CoV-2感染状态相关联.
主要方法:
- 一项横截面研究调查了美国红十字会献血者 (≥18岁) 关于自2020年3月以来的新长期症状.
- 根据自我报告或抗核囊抗体阳性来确定SARS-CoV-2感染.
- 血清检测是在2020年6月至2021年12月期间进行的.
主要成果:
- 超过238,000名参与者符合纳入标准;43.3%的SARS-CoV-2感染者报告了新的长期症状,而没有感染者则为22.1%.
- 感染SARS-CoV-2的个体出现新的长期症状的几率是2.55倍 (AOR,2.55;95% CI,2.51-2.61).
- 与味道/气味和呼吸道/心脏问题相关的长期症状与先前感染最强烈相关.
结论:
- 长期症状在有SARS-CoV-2感染史的人群中更为普遍.
- 女性性别和先前存在的慢性疾病与症状报告的增加有关.
- 用对照组和血清学数据进行进一步的研究对于理解和跟踪长期COVID-19后果至关重要.
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