低血症对儿童创伤患者的死亡率的影响,这些患者需要输血
Elissa Abou Khalil1, Erin Feeney, Katrina M Morgan
1From the Department of Surgery (E.A.K.), Northwestern University, Evanston, IL; University of Pittsburgh Medical Center, Department of Surgery, Pittsburgh, PA (E.F., K.M.M., P.C.S., C.M.L.); and University of Texas Southwestern, Department of Surgery, Dallas, TX (B.A.G.).
The journal of trauma and acute care surgery
|April 8, 2024
概括
儿科创伤患者的低血与较高的死亡率和增加的血液产品输血有关. 对这些严重受伤的儿童及时给予的益处需要进一步的研究.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 创伤外科手术是什么
- 紧急医疗 紧急医疗
背景情况:
- 入院低血是已知预测成年创伤患者不良结果的预测因素.
- 缺血症和儿科创伤死亡率之间的关联仍未得到充分研究.
研究的目的:
- 研究入院低血症对儿科创伤患者住院死亡率和血液制品需求的影响.
- 为了确定缺血症是否是这个人群中死亡率的独立预测因素.
主要方法:
- 对儿科创伤中心数据库 (2013-2022) 的回顾性分析.
- 纳入标准:受伤后24小时内接受输血的儿童 (<18岁) 具有入院的电离 (iCal) 水平.
- 排除标准:抵达前大量输血或测试前给予.
- 低血症被定义为iCal <1.00.00. 这样.
- 结果:住院死亡率和24小时血液制品需求.
- 调整后勤回归以损伤严重性得分 (ISS),冲击指数,格拉斯哥昏迷表 (GCS) 和输血量为准.
主要成果:
- 包括331名儿童;10%的人患有低血症.
- 低血症儿童的ISS得分较高,GCS得分较低.
- 低血症与显著增加的住院 (56%vs. 18%) 和24小时 (28%vs. 5%) 死亡率相关 (p < 0.001).
- 低血症队列接受了更多的血液制品 (22毫升/公斤更多).
- 在调整后,低血症独立预测24小时 (OR 4.93) 和住院死亡率 (OR 3.41) 的增加.
结论:
- 入院低血是儿童创伤死亡的一个独立风险因素.
- 低血症与受伤儿童更大的血液产品输血需求有关.
- 在儿科创伤中早期服用的潜在益处需要进一步研究.
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