相关实验视频

Updated: May 6, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

巨细胞激活标志物与急性肝衰竭患者的感染和死亡率有关

Anna Cavazza^1,2, Evangelos Triantafyllou³, Roberto Savoldelli⁴

¹Department of Inflammation Biology, School of Inflammation and Microbial Science, Institute of Liver Studies, King's College London, London, UK.

Liver international : official journal of the International Association for the Study of the Liver

|April 8, 2024

概括

像sCD206这样的巨细胞激活的可溶性标记物 (MAM) 在急性肝衰竭 (ALF) 患者中升高,与感染和死亡风险相关. sCD206作为毒症和ALF.生存的生物标志物显示出希望.

科学领域:

免疫学免疫学免疫学
肝病学肝病学是一种肝病学.
生物标志物发现发现

背景情况:

急性肝衰竭 (ALF) 是一种严重的疾病,死亡率高,通常需要进行肝移植.
天生的免疫系统激活在肝损伤期间释放可溶性巨细胞激活标记物 (MAMs).
在ALF中MAM的预后价值需要进一步调查.

研究的目的:

探索MAMs与ALF患者的疾病严重程度,感染和预后之间的关联.
调查sCD206和sCD163作为ALF潜在生物标志物的作用.

主要方法:

从ALF患者 (n=264) 和健康对照组 (n=50) 的血清样本使用ELISA分析了MAM.
MAM与临床严重性标志物和21天生存率相关.
流细胞计评估了ALF患者中CD206的CD14+单细胞表达.

主要成果:

与对照组相比,ALF患者的MAM明显高于对照组.
sCD206水平与细菌病和一般感染相关.
在经MELD调整的模型中,sCD206和sCD163独立与死亡率相关.
单细胞上的CD206表达在ALF患者中较高,与SOFA得分相关.
sCD206在外部队列中被验证为感染预测因子.

结论:

sCD206在患有感染和不良结果的ALF患者中升高,并在单细胞上升调节.
随着时间的推移,sCD163和sCD206的测量可以预测ALF的死亡率.
sCD206值得进一步研究,作为ALF中败血症和死亡率的生物标志物.

关键词:

急性肝衰竭是一种严重的肝衰竭.这是先天免疫力.巨细胞是什么?巨细胞是什么?器官衰竭器官衰竭是指器官的缺陷.已经有了血症.

更多相关视频

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

相关概念视频

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Cirrhosis II: Pathophysiology

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...