在第一次对勃起功能障碍进行调查时,PDE5is-naive与非naive患者 - 从长期,现实生活的横截面研究中得出的结果
Simone Cilio1,2, Paolo Capogrosso3, Edoardo Pozzi1,4
1Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
Andrology
|April 8, 2024
概括
许多男性在没有处方的情况下使用固酶5抑制剂 (PDE5is) 治疗勃起功能障碍,尽管这一趋势正在下降. 教育活动对于确保安全有效地使用这些药物至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 男人的健康 男人的健康
背景情况:
- 固酶5抑制剂 (PDE5is) 是勃起功能障碍 (ED) 的首要治疗方法.
- 有相当数量的男性在没有正式的医疗处方的情况下获得PDE5is,有时是出于非医疗原因.
研究的目的:
- 在任何正式的医疗咨询之前,调查使用PDE5is治疗ED的患者的临床特征.
- 随着时间的推移,分析PDE5is自我处方的趋势.
主要方法:
- 从2005年至2022年期间寻求初步ED治疗的2012年男性的数据分析.
- 根据之前的使用情况,患者被分为PDE5i-naive或非PDE5i-naive.
- 临床数据包括病史,国际勃起功能指数 (IIEF) 和查尔森并发症指数 (CCI).
- 统计分析包括逻辑和线性回归模型.
主要成果:
- 在第一次评估时,70.9%的患者是PDE5i-naive.
- 之前没有PDE5i的患者通常更年轻,并患上较少的并发病 (较低的CCI) 和更好的基线勃起功能 (较高的IIEF-EF得分).
- 与PDE5i-naive相关的因素包括较低的BMI,较高的IIEF-EF得分,ED的严重程度较低,以及较早的评估时间.
结论:
- 自我处方PDE5is很普遍,但随着时间的推移而下降.
- 促进教育活动至关重要,以突出PDE5的安全和有效使用,同时阻止滥用.
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