药物管理错误类型:与轻度认知障碍亚型相关
Alyssa N De Vito1,2, Sheina Emrani3, Emily Hallowell1,4
1Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
The Clinical neuropsychologist
|April 8, 2024
概括
患有多领域轻度认知障碍 (MCI) 的老年人犯了更多的药物错误. 单域MCI患者表现出更多的坚持性错误,可能会过度补偿记忆丧失.
科学领域:
- 老年学是一门学科.
- 神经心理学 神经心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物管理错误是老年人,特别是那些有认知障碍的人的一个重大问题.
- 轻度认知障碍 (MCI) 呈现出一个频谱,对日常功能产生不同的影响.
研究的目的:
- 调查和比较认知正常 (CN) 的老年人和单域记忆力MCI (sdMCI) 和多域记忆力MCI (mdMCI) 的模拟药物服用错误.
- 识别与不同MCI亚型相关的特定类型的错误,包括遗漏,委托和坚持.
主要方法:
- 使用药物管理能力评估 (MMAA) 版本4.1,一个基于绩效的任务,有266名参与者 (CN,sdMCI,mdMCI).
- 采用克鲁斯卡尔-瓦利斯H测试来分析总分数,准确性和错误类型的群体差异.
- 引入并运行了"持久性错误",即多次服用剂量.
主要成果:
- 与CN和sdMCI组相比,mdMCI患者的整体表现 (MMAA得分) 显著降低.
- mdMCI组表现出更高的遗漏错误 (错过的剂量) 的频率.
- sdMCI集团比CN集团犯了更多的坚持性错误,而在佣金错误方面没有观察到集团之间的显著差异.
结论:
- 多域MCI与对药物管理困难的更高脆弱性有关.
- 在sdMCI中持续性错误可能表明对记忆缺陷的补偿策略.
- 需要进一步的研究来将MMAA的性能与不同人群中的真实世界药物坚持相关联.
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