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了解微气泡度对超分辨率超声波成像定位精度的影响

Marcelo Lerendegui¹, Jipeng Yan¹, Eleanor Stride²

¹Department of Bioengineering, Imperial College London, London, United Kingdom.

Physics in medicine and biology

|April 8, 2024

概括

超分辨率超声波 (SRUS) 成像面临着高微泡度 (MB) 的挑战. 邻近的MB干扰会导致显著的局部化错误,影响深层组织成像的准确性.

科学领域:

医疗成像医学成像
生物医学工程生物医学工程
声学声学在声学方面

背景情况:

超分辨率超声波 (SRUS) 可实现微血管的亚波长成像.
SRUS依赖于个别微气泡 (MB) 的准确定位.
来自密切间隔的MB的信号干扰可能会损害定位的准确性.

研究的目的:

为了研究微气泡到微气泡距离对超声波图像定位的影响.
了解成像参数如何影响由MB干扰引起的本地化错误.

主要方法:

模拟超声波场传播和非线性MB动态.
分析的MB-MB距离,MB大小,超声频率,脉冲序列,振幅和定位方法.
模拟的临床线性阵列 (6 MHz) 和心脏 (1.5 MHz) 探针.

主要成果:

增加MB度导致由于干扰边缘的振荡局部化错误.
20-30μm (1/10波长) 的定位错误发生在~500μm的距离 (6MHz).
误差达到200μm (1/5波长) 在>10波长的隔离 (1.5MHz).
密切的MB经常被检测为一个单一实体.

结论:

建议在SRUS成像中谨慎使用高MB度和<1.7-3xPSF的分离.
MB-MB干扰显著影响SRUS中的定位精度.
定位错误取决于MB分离和成像参数.

关键词:

对比度增强,增强了对比度.这些微小气泡是微型气泡.超级分辨率超声波超声波的使用超声波定位显微镜学超声波定位显微镜学

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