组织纤维细胞是多功能免疫调节剂:对它们对衰老过程的影响的评估
Antero Salminen1, Kai Kaarniranta2, Anu Kauppinen3
1Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio FI-70211, Finland.
Ageing research reviews
|April 8, 2024
概括
纤维细胞是组织中的关键免疫调节体,在促炎和免疫抑制作用之间转移. 它们与免疫细胞的复杂相互作用显著影响衰老和与年龄相关的疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 组织工程是组织工程.
背景情况:
- 纤维细胞是维持细胞外基质 (ECM) 完整性和调节组织免疫力的关键 stromal 细胞.
- 组织结构细胞,包括纤维细胞,表现出器官特异性免疫力,并与免疫细胞密切相互作用.
- 纤维细胞动态调节免疫特性,显示取决于环境的促炎和免疫抑制活动.
研究的目的:
- 探索纤维细胞在组织恒温和疾病中的多方面的免疫作用.
- 在急性和慢性病理条件下研究纤维细胞和免疫细胞之间的相互作用.
- 了解纤维细胞免疫特性对衰老和与年龄有关的疾病的贡献.
主要方法:
- 在老化组织中分析纤维细胞免疫基因表达.
- 在各种病理状态下研究纤维细胞-免疫细胞相互作用.
- 单细胞转录组研究以表征纤维细胞异质性.
主要成果:
- 纤维细胞表现出促炎和免疫抑制的功能,适应不同的组织环境和侮辱.
- 在慢性疾病中,衰老性纤维细胞及其与免疫抑制细胞 (例如M2巨细胞,MDSC) 的相互作用会加剧纤维化.
- 单细胞转录组学揭示了老化的纤维细胞表达免疫因子,但减少了纤维基因基因.
结论:
- 纤维细胞在编排组织免疫和炎症方面发挥着关键作用.
- 纤维细胞的动态免疫行为在纤维化和与年龄有关的疾病的发病过程中至关重要.
- 准纤维细胞-免疫细胞交叉呈现了一个潜在的治疗策略,对衰老和相关的病理.
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