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一个开源的MRI兼容框架,用于和子的多式手术前测绘

Lucy Liang¹, Isabela Zimmermann Rollin², Aydin Alikaya³

¹Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.

Journal of neuroscience methods

|April 8, 2024

概括

一种新的紧型MRI兼容的立体影像技术,可以在非人类灵长类动物中实现精确的神经外科准. 这种3D打印设备可以改善多式联络成像对齐,用于先进的研究应用.

科学领域:

神经外科神经外科
灵长类动物研究研究
医疗成像医学成像

背景情况:

非人类灵长类动物 (NHPs) 的高精度神经外科手术依赖神经成像 (MRI,CT,PET) 进行解剖绘图.
将成像坐标与立体毒性装置对齐是具有挑战性的,因为组织对比度不同.
现有的MRI兼容的立体影像系统通常与高分辨率的合规头卷不兼容.

研究的目的:

为非人类灵长类动物 (NHPs) 开发一个紧的,MRI兼容的立体成像.
为了使用特定技术的信任标记来实现多式联络图像对齐.
创建一个用户友好和成本效益的解决方案,用于NHP神经外科手术的术前规划.

主要方法:

设计了一个紧的,MRI兼容的立体影像,可以适应各种NHP物种.
纳入技术特定的多式调整信托标记 (MRI,CT,PET).
确保与临床成像系统和标准立体毒性操作的兼容性,而不需要标记器植入或特殊软件.

主要成果:

通过MRI内管插入和病毒载体注射,证明了准确的信托系统性能.
在深层大脑电生理学中用于机器人电极植入的验证多式调整 (MRI/CT).
在各种神经外科实验中证实了该装置在手术前规划中的适用性.

结论:

开发了一种多功能,可3D打印,MRI兼容的用于NHP神经外科的立体影像.
模块化设计提供了低成本和可管理的制造.
公共可用的设计文件促进了灵长类神经外科研究的更广泛采用和创新.

关键词:

脑子脑子脑子脑子卡普奇尼人是一个卡普奇尼人.计算机断层扫描 (CT) 是一种计算机断层扫描.澳门澳门澳门澳门磁共振成像技术磁共振成像技术定子发射断层扫描 (PET) 是一种定子发射断层扫描.立体有毒的框架框架

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