相关实验视频

Updated: Jun 29, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

细胞外囊泡在抵抗割的前列腺癌中的作用

Chaoyu Liao¹, Zeyu Huang¹, Jingui Liu¹

¹Department of Urology, Urologic Surgery Center, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.

Critical reviews in oncology/hematology

|April 8, 2024

概括

细胞外囊泡 (EVs) 介导割耐性前列腺癌 (CRPC) 的传播,影响其进展和耐药性. 研究探讨了EVs作为生物标志物和CRPC的潜在治疗工具.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

前列腺癌 (PCa) 构成全球健康风险,抗割PCa (CRPC) 是PCa死亡的主要原因.
细胞外囊泡 (EVs) 是关键的细胞间通信器,转移影响受体细胞功能的分子载荷.
癌细胞和瘤微环境分泌的EV在CRPC发育,进展和治疗耐药性方面发挥着作用.

研究的目的:

审查当前对细胞外囊泡参与割抵抗性前列腺癌的理解.
通过液体活检强调EVs作为诊断和预后生物标志物的潜力.
讨论EVs在CRPC管理中的治疗影响.

主要方法:

在前列腺癌中研究细胞外囊泡的研究文献综述.
对电动汽车货物的研究分析及其在CRPC进展和耐药性方面的作用.
检查CRPC中EV临床应用的当前挑战和未来方向.

主要成果:

EVs与CRPC发生,进展和耐药性的发展有关.
在生物流体中发现的EV显示为用于CRPC诊断,预后和监测治疗反应的非侵入性生物标志物具有前途.
技术障碍目前限制了基于EV的生物标志物的广泛临床采用.

结论:

细胞外囊泡是割抵抗性前列腺癌中显著的调解者.
电动车具有作为CRPC有价值的生物标志物和新型治疗策略的基础的潜力.
需要进一步的研究来克服技术挑战,并促进CRPC中EV应用程序的临床翻译.

关键词:

生物标志物生物标志物抗割的前列腺癌是什么?药物耐药性药物耐药性药物耐药性细胞外囊泡细胞外囊泡瘤微环境瘤微环境

更多相关视频

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Receptor Downregulation in MVBs

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...

Overview of Secretory Vesicles

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...