维生素D缺乏肺结核患者补充维生素D治疗的影响:一项随机,双盲,主动控制的临床试验
Harish Chandra1, Adil Rahman1, Prashant Yadav2
1Department of Biochemistry, Academic Block, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, (U.P), 206130, India.
The Indian journal of tuberculosis
|April 8, 2024
概括
补充维生素D3治疗通过减少炎症和增强免疫反应显著改善了肺结核患者的临床结果. 这项研究没有发现任何不良影响,这表明维生素D3是标准结核病治疗的安全有效补充.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 维生素D调节先天性和适应性免疫力,可能有助于结核病 (TB) 管理.
- 结核病患者经常出现维生素D缺乏,影响免疫功能和疾病进展.
- 辅助维生素D治疗可能有助于平衡免疫活性,并减少结核病中的组织损伤.
研究的目的:
- 评估辅助维生素D3对肺结核患者结核病预后的影响.
- 评估维生素D对炎症标志物和临床参数的影响.
- 确定维生素D3补充剂在缺乏维生素D的结核病患者中的安全性和有效性.
主要方法:
- 一项前性,随机,双盲,安慰剂对照试验,涉及130名肺结核患者.
- 患者接受了标准的抗结核治疗,包括或不含维生素D3 (4剂6周).
- 监测的关键变量包括白细胞计数差异,ESR,炎症标志物,SpO2,体重和血清水平.
主要成果:
- 补充维生素D3显著降低了中性粒细胞数量和增加了淋巴细胞数量.
- 红细胞沉积率,腺氨酸脱氨酶和C反应蛋白水平的改善被观察到.
- 接受维生素D3治疗的患者的氧和和体重显著增加,没有报告过高血症.
结论:
- 辅助维生素D3可以加速肺结核炎症炎症反应的解决.
- 维生素D3补充改善了结核病患者的临床结果和免疫参数.
- 这项研究支持使用维生素D3作为肺结核的安全有效辅助疗法.
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