在发育上独特的小脑处理优先考虑自我而不是其他产生的运动
Angela M Richardson1, Greta Sokoloff2,3, Mark S Blumberg4,2,3
1Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa 52242.
概括
年轻的老鼠通过小脑学会区分自己产生的运动与外部刺激. 这项研究揭示了随机放电和重现如何在睡眠动期间集成,以开发内部模型.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 小脑对于运动控制和学习至关重要,利用内部模型.
- 区分自我生成 (反应) 和外部 (外移) 传感输入对于运动控制至关重要.
- 内部模型在大鼠中在出生后的前三周内发展,这一过程尚未完全理解.
研究的目的:
- 调查小脑内在出生后生命早期的内部模型的发展.
- 为了检查在主动 (REM) 睡眠动期间,大脑中深层小脑核 (插座,IP) 如何处理后果性放电和重现.
- 为了测试大脑小脑皮质活动在IP中调节恶性信号处理的假设.
主要方法:
- 在生后第12天 (P12) 的老鼠中,在活性 (REM) 睡眠期间,从插座 (IP) 中核的记录.
- 比较神经元对自我产生的抽 (回应) 和外部四肢刺激 (超应) 的反应.
- 调查尿麻醉和皮质剥离对IP中恶性反应的影响.
主要成果:
- 大多数IP单元对自我生成的抽 (回应) 作出了强有力的反应.
- 相对较少的IP单元显示出加剧的反应,与其他感官区域不同.
- 尿麻醉和皮质剥离在IP中增加了恶性反应,支持小脑皮层的抑制作用.
- 与抽相关的尾随性释放和重现与小脑皮层和IP平行传递.
结论:
- 发育中的小脑,通过结合伴随性放电和睡眠动期间的重现,构成了内部模型开发的基础.
- 小脑皮质在将干扰信号传送到深小脑核中起着抑制作用.
- 这些发现阐明了传感运动集成和预测运动控制的关键发育机制.
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