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Updated: Jun 29, 2025

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加快体质突变要求从异质瘤样本中获得全基因组和全外体测序数据

Shuangxi Ji1, Tong Zhu2, Ankit Sethia2

  • 1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Genome research
|April 8, 2024
PubMed
概括

MuSE 2提高了癌症基因组学中的体质突变检测速度. 这种工具显著减少了计算时间,提高了分析大型癌症基因组数据集的效率.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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