替代疗法与心血管结果之间的关联:对30项随机对照试验的元分析
Vikash Jaiswal1, Aanchal Sawhney2, Chikodili Nebuwa3
1Department of Cardiovascular Research, Larkin Community Hospital, South Miami, FL, USA.
Progress in cardiovascular diseases
|April 8, 2024
概括
替代疗法 (TRT) 治疗低血球症并不会增加心血管疾病 (CVD) 的风险或死亡率. 这项对30项试验的元分析发现TRT和安慰剂组之间的心血管疾病事件,中风,心脏病发作和死亡率相似.
科学领域:
- 内分泌学和新陈代谢学
- 心血管医学 心血管医学
- 临床试验 临床试验
背景情况:
- 替代疗法 (TRT) 在低腺男性的心血管安全性仍然不确定.
- 需要对TRT对心血管疾病 (CVD) 结果的影响进行全面评估.
研究的目的:
- 评估接受治疗的男性心血管疾病 (CVD) 结果.
- 综合最近发表的随机对照试验 (RCT) 的证据.
主要方法:
- 在PubMed,EMBASE和ClinicalTrials.gov.gov的系统文献搜索.
- 包括相关的随机对照试验 (RCT) 到2023年9月30日.
- 主要和次要心血管疾病结局的聚合分析.
主要成果:
- 分析了30个RCT,其中包括11,502名患者.
- 在TRT和安慰剂之间,任何心血管疾病事件 (OR 1.12) 的发生率,中风 (OR 1.01) 或心肌梗塞 (OR 1.05) 的发生率没有显著差异.
- 观察到可比的全因死亡率 (OR 0.94) 和心血管疾病死亡率 (OR 0.87).
结论:
- 替代疗法 (TRT) 似乎不会增加心血管风险.
- 与安慰剂相比,TRT与可比的全因死亡率和心血管疾病死亡率有关.
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