成年人的骨矿物质密度与arthrogryposis多重先天性:一个回顾性队列分析
X Romand1, R Gastaldi2, D Pérennou3
1T-RAIG, TIMC, CNRS, UMR 5525, University of Grenoble Alpes, Grenoble-Alpes University Hospital, 38000, Grenoble, France. xromand@chu-grenoble.fr.
Scientific reports
|April 8, 2024
概括
患有多发性先天性关节炎 (AMC) 的成年人通常具有低关节骨矿物质密度 (BMD) 和维生素D不足. 对于早期干预,建议对低BMD和维生素D水平进行查.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 综合性先天性关节 (Arthrogryposis multiplex congenita,简称AMC) 是一种罕见的疾病,其特征是多重关节收缩.
- 患有AMC的成年人骨矿物质密度 (BMD) 和维生素D状况尚未得到充分记录.
- 了解这些因素对于管理AMC患者的长期骨健康至关重要.
研究的目的:
- 确定患有AMC的成年人骨矿物质密度 (BMD) 低的股骨和腰椎骨矿物质密度的流行率.
- 为了评估这个人群中的维生素D水平.
- 为了确定BMD,维生素D和临床因素之间的潜在相关性.
主要方法:
- 来自法国参考中心和PARART注册表的AMC成年人的回顾性队列分析.
- 双能X射线吸收计 (DXA) 用于骨损伤的评估.
- 测试25-氧维生素D水平的测试.
主要成果:
- 与一般人群相比,平均股骨部和部总体BMDZ得分显著降低.
- 22.5%和25%的患者分别具有较低的股骨部和部总体BMDZ得分.
- 86.1%的患者表现出维生素D缺乏 (25-氧维生素D<75nmol/L).
- 腿部部和部 BMD 与身高和水平相关.
- 49%的患者报告有骨折.
结论:
- 患有AMC的成年人表现出比预期的更低的部骨质量,以及维生素D缺乏的高患病率.
- 对于患有AMC的成年人,建议使用DXA和维生素D补充剂查低BMD.
- 对于那些有跌倒或骨折史的人来说,查的考虑尤其重要.
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