在恐惧调节过程中,杏仁体和海马体反应的变化与迫害信念有关
Wisteria Deng1,2, Lauri Tuominen1,3, Rachel Sussman1
1Department of Psychiatry, Massachusetts General Hospital, 149 13th, St. Charlestown, Boston, MA, 02129, USA.
Scientific reports
|April 8, 2024
概括
具有迫害信仰的年轻人表现出杏仁体和海马体的关联性学习受损. 中间叶功能的这种干扰可能是精神病症状的基础.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 迫害妄想在精神病中很常见,但其神经生物学基础尚不清楚.
- 以前的研究表明,中叶 (MTL) 协会学习缺陷可能参与其中.
- 这项研究研究了患有亚临床迫害思维的个体的MTL功能.
研究的目的:
- 检查具有和没有迫害信仰的年轻成年人的协会学习差异.
- 在这种背景下,研究杏仁体和海马体在恐惧调节中的作用.
- 探索亚临床精神病症状与MTL反应之间的关系.
主要方法:
- 在64名健康的年轻成年人中,在帕夫洛夫恐惧调节期间进行fMRI.
- 参与者看到了与轻微电击相配对 (CS+) 或不配对 (CS-) 的面孔.
- 测量了杏仁体,海马体,突出和默认网络中的神经反应.
主要成果:
- 健康的参与者对CS-vs-CS+显示出更大的杏仁体和海马体反应.
- 具有迫害信仰的参与者未能表现出这种差异性反应.
- 这种MTL关联性学习缺陷与亚临床精神病症状严重程度相关.
结论:
- 研究结果表明,在患有亚临床迫害思维的人群中,MTL依赖的关联学习受损.
- 这种干扰可能代表了一种导致精神病的神经生物学机制.
- 结果突出了杏仁体和海马体在迫害妄想中的作用.
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