相关实验视频

Updated: Jun 26, 2026

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

神经退行性生物标志物阳性运动员与重复脑震荡的功能性连接性变化

Indira Garcia-Cordero^1,2, Anna Vasilevskaya¹, Foad Taghdiri¹

¹Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.

Journal of neurology

|April 8, 2024

概括

神经退行性生物标志物可以检测患有痴呆风险的前运动员重复脑震荡,即使具有正常认知能力. 改变默认模式的网络连接,与脑震荡相关,表明潜在的未来神经退行.

科学领域:

神经科学是一个神经科学.
运动医学运动医学
生物标志物研究生物标志物研究

背景情况:

接触运动中重复性脑震荡与长期的神经问题有关,包括痴呆症.
识别运动员神经退行早期症状对于及时干预至关重要.
多模式生物标志物在检测有风险的个体方面表现有前途.

研究的目的:

研究神经退行生物标志物与前运动员重复脑震荡的认知/情绪结果之间的关联.
检查与生物标志物状态有关的脑缩和功能连接.
探索神经退行性生物标志物,大脑变化和体育史之间的联系.

主要方法:

评估了41名脑震荡重复的前运动员,根据血清神经丝光链分为生物标志物阳性和阴性组.
进行了认知,情绪和行为评估.
使用ANCOVA和回归,控制年龄和内体积,分析了关键大脑网络 (DMN,突出,前) 的灰质体积和功能连接性.

主要成果:

在生物标志物阳性和阴性运动员组之间,没有发现认知,情绪/行为得分或灰质体积的显著差异.
与健康对照组和生物标志物阴性组相比,生物标志物阳性组的默认模式网络 (DMN) 连接性减少.
默认模式网络断开与运动员遭受的脑震荡数量相关.

结论:

血清神经纤维光链可以作为生物标志物,用于检测前运动员脑震荡史的神经退行.
改变的DMN连接,即使在认知正常的运动员中,也可能表明痴呆的风险增加.
通过生物标志物和功能连接分析进行早期检测对于管理运动员的长期风险至关重要.

关键词:

缩性缩症缩性缩症生物标志物生物标志物脑震荡是一种脑震荡.功能连接性的功能连接性.神经退行发生神经退行.

更多相关视频

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Published on: April 18, 2019

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Alterations in Muscle Tone lll

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...