和对肉生长性能和功能的联合影响
Man Zhao1, Longqiang Xie1, Wenbin Huang1
1Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, 430070, China.
Biological trace element research
|April 8, 2024
概括
肉中的重金属 (Cd) 和 (Pb) 暴露显著降低了生长性能,并导致脏损伤. 结合Cd和Pb的暴露比单个暴露产生更大的负面影响,涉及细胞内膜网膜应激.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 毒理学 毒理学 毒理学
- 动物营养 动物营养
背景情况:
- (Cd) 和 (Pb) 是环境重金属,影响畜牧业生产,并在组织中积累.
- 脏是Cd和Pb毒性的首要目标,影响再吸收和骨健康.
- 关于Cd和Pb对牲畜表现,骨强度和损伤的联合影响的研究有限.
研究的目的:
- 研究Cd和Pb对 brojler生长性能和功能障碍的联合作用.
- 阐明Cd和Pb诱导的氧化损伤的潜在机制.
主要方法:
- 168只罗斯308肉被分为四个组:控制组,只有Cd,只有Pb,以及Cd和Pb的组合.
- 增长表现指标 (料摄入量,体重增加,料益比率) 被记录在6周内.
- 用显微镜和超结构分析脏组织以评估损伤.
主要成果:
- 同时暴露于Cd和Pb显著降低了平均每日料摄入量和平均每日体重增加.
- 在Cd和Pb联合暴露6周后,给益率显著增加.
- Cd和Pb诱导损伤,在联合暴露组中观察到更严重的影响,包括管状退化和间歇性静止.
结论:
- 饮食中的Cd和Pb暴露会损害肉生产性能,并导致脏氧化损伤.
- 与单个暴露相比,Cd和Pb的联合暴露会加剧损伤.
- 该PERK-ATF4通路,介导内质网膜压力,与慢性Cd和Pb暴露的氧化损伤有关.
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