支气管膜洗,支气管洗和唾液培养之间的协议:一个回顾性研究
Anne-Eva Post1, Erik Bathoorn2, Douwe F Postma3
1Department of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Infection
|April 8, 2024
概括
支气管洗显示出与支气管膜洗在诊断常见病原体如金黄色葡萄球菌和Pseudomonas aeruginosa方面的良好一致性,为侵入性手术提供了潜在的替代方案.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 诊断微生物学 诊断微生物学
背景情况:
- 支气管支气管洗 (BAL) 是未解决的肺炎的标准诊断工具.
- BAL是侵入性的,可能会损害患者的氧化,需要探索替代方案.
- 与BAL相比,支气管洗 (BW) 和唾液的诊断实用性仍在争论中.
研究的目的:
- 为了比较各种病原体的BAL和BW的诊断准确性.
- 为了二次比较BAL和唾液的诊断准确性.
- 评估下呼吸道感染的替代诊断方法.
主要方法:
- 对接受BAL,BW和唾液采样 (2018-2021) 的成年患者的回顾性分析.
- 计算类内相关系数 (ICC) 以评估方法之间的一致性.
- 包括病原体数据,如金黄色葡萄球菌,Pseudomonas aeruginosa,Stenotrophomonas maltophilia和Aspergillus fumigatus等病原体.
主要成果:
- 在S. aureus和P. aeruginosa的BAL和BW之间观察到高的ICC值 (0.819-0.865).
- 在S. maltophilia和A. fumigatus的BAL和BW之间发现了中等的ICC值 (0.568-0.624).
- 在BAL和唾液分析之间发现了不同程度的一致性.
结论:
- 支气管洗显示了与支气管膜洗对关键细菌病原体的实质性一致.
- 在临床环境中,支气管洗可以作为BAL的可行,不那么侵入性的替代方案.
- 进一步的研究可以验证BW在诊断更广泛的呼吸道感染的作用.
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