复星对精炼烟雾引起的炎症损伤的保护作用
Yu-Lin Pan1, Rui-Ze Wu1, Yao Fu1
1Department of Occupational Health, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150086, Heilongjiang Province, People's Republic of China.
Cell biochemistry and biophysics
|April 8, 2024
概括
烟气通过增加ROS和激活NLRP3炎症酶引起肺炎. ресвератрол通过激活SIRT1,抑制NF-κB,并通过SIRT1-NF-κB-NLRP3通路减少炎症来保护肺细胞.
科学领域:
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- (Ni) 是一种有毒的金属,会引起呼吸道炎症.
- 复星 (Res) 具有抗炎性质.
研究的目的:
- 研究Ni-精炼烟雾对肺细胞的毒性.
- 阐明复星对Ni诱导的炎症的保护机制.
主要方法:
- 使用人类肺支气管上皮细胞 (BEAS-2B) 的体外研究.
- 使用Wistar大鼠肺组织进行体内研究.
- 分析反应性氧物种 (ROS),NLRP3炎症酶,IN-1β (IL-1β),sirt1 (SIRT1) 和核因子-kappaB (NF-κB) 途径.
主要成果:
- 精炼烟雾诱导细胞损伤,增加ROS,激活NLRP3炎症组,并促进IL-1β分泌.
- ресвератрол (20μmol/L) 激活了SIRT1,抑制了NF-κB,并降低了NLRP3炎症酶激活和IL-1β过度表达.
- Resveratrol在Wistar大鼠中缓解了Ni诱导的急性炎症性肺损伤.
结论:
- 复星通过SIRT1-NF-κB-NLRP3通路对Ni-精炼烟雾毒性的抗炎作用.
- 这项研究为开发重金属引起的职业炎症伤害的保护药物提供了基础.
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