通过Vitex negundo种子减轻由莱特醇诱导的多囊性卵巢综合征相关的炎症反应和内分泌功能障碍
Tarun Kumar Kar1, Sananda Sil1, Angshita Ghosh1
1Department of Biomedical Laboratory Science & Management, Vidyasagar University, Midnapore, West Bengal, India.
Journal of ovarian research
|April 8, 2024
概括
维特克斯negundo种子提取物通过恢复荷尔蒙平衡和减少炎症,有效地治疗大鼠的多囊卵巢综合征 (PCOS). 这种天然疗法由于其抗氧化和抗炎性质,对PCOS管理有很大的希望.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种复杂的内分泌疾病,需要安全有效的治疗方法.
- 目前对PCOS的治疗选择往往具有局限性,需要探索替代疗法.
研究的目的:
- 为了评估Vitex negundo种子提取物的治疗疗效,在Letrozole诱导的PCOS大鼠模型中.
- 研究Vitex negundo在PCOS中的作用的潜在机制.
主要方法:
- 在使用莱特醇的老鼠中诱导PCOS.
- 使用水乙醇Vitex negundo提取物 (VNE) 的方法.
- 生物化学分析,荷尔蒙检测,抗氧化酶水平评估,细胞因子分析,亡标志物评估,LC-MS植物化学分析,分子对接和卵巢组织形态学评估.
主要成果:
- 在PCOS大鼠中,VNE的使用恢复了内分泌代谢失衡,纠正了抗氧化酶,促炎细胞因子和亡标志物.
- 在VNE中,LC-MS发现了酸,素和尼古丁B,它们表现出低血糖,低脂和减肥效应.
- 通过影响ERα信号传递和NR3C4表达,VNE调节了类固醇酶,性腺激素和LH:FSH比,表现出抗氧化,抗炎和抗芽作用.
结论:
- 维特克斯negundo种子提取物为PCOS提供了一个有希望的,多方面的治疗选择.
- 提取物的有效性归因于其关键的植物化学物质,提供抗素,抗炎和抗氧化剂的好处.
- 通过对荷尔蒙平衡,炎症和氧化应激的影响,VNE提供了一种全面的方法来管理PCOS.
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