先天性心脏病与神经发育障碍的关联:一项观察性和门德尔随机化研究
Zhi-Yuan Liu1,2, Qiong-Qiong Wang1, Xian-Yong Pang1,2
1Department of Cardiology, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Italian journal of pediatrics
|April 8, 2024
概括
患有先天性心脏病 (CHD) 的儿童面临神经发育障碍 (NDD) 的更高风险. 当前的心脏病及其严重程度也与ADHD和自闭症等NDD有关.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 神经发育儿科 神经发育儿科
- 遗传学 是一个遗传学.
背景情况:
- 在全球范围内,先天性心脏病 (CHD) 影响着数百万儿童.
- 神经发育障碍 (NDD) 在儿童发育中存在重大挑战.
- CHD和NDD之间的复杂关系需要进一步调查.
研究的目的:
- 研究先天性心脏病 (CHD) 和神经发育障碍 (NDD) 之间的关联.
- 探索当前心脏病及其严重程度对NDD风险的影响.
- 使用孟德尔随机化 (MR) 区分观察关联和潜在的因果关系.
主要方法:
- 利用国家儿童健康调查 (2020-2021) 的数据进行观察性研究.
- 采用多变量逻辑回归和倾向得分匹配 (PSM) 来控制混因素.
- 应用了门德尔随机化 (MR) 与反向方差加权,加权中位数和MR-Egger方法来评估因果关系.
主要成果:
- 观察分析揭示了心脏病,当前的心脏病和NDD之间的关联,包括言语/语言障碍,ADHD,智力障碍和自闭症.
- 倾向性得分匹配证实了CHD和ADHD,智力障碍和言语/语言障碍之间的显著关联.
- 门德尔随机化分析没有确定基因代理先天性心脏形和NDD风险之间的因果关系.
结论:
- 患有心脏病的儿童患有NDD的风险较高.
- 当前心脏病的存在和严重程度与NDD有显著的关联.
- 需要使用先进的方法进行进一步的研究,以阐明CHD和NDD之间的因果关系.
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