介质细胞干细胞诱导在下垂体瘤中的免疫抑制微环境
Daniel Marrero-Rodriguez1, Victor A Cortes-Morales1,2, Amayrani Cano-Zaragoza1
1Unidad de Investigación Médica en Enfermedades Endócrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico.
The Journal of clinical endocrinology and metabolism
|April 8, 2024
概括
在垂体瘤 (PTs) 中的介质干细胞 (MSCs) 具有免疫抑制特性,可能导致瘤生长. 确定了两个不同的MSC亚群,来自瘤的亚群比来自正常腺体的亚群表现出更大的免疫抑制.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 瘤微环境 (TME) 包含多种细胞,包括介质干细胞 (MSC),可以促进瘤生长.
- 脑瘤中MSCs的作用以前没有被研究过.
研究的目的:
- 为了调查MSCs在人体垂体瘤中的存在和功能.
- 来自PT的MSC与来自非瘤垂体腺的MSC进行比较.
主要方法:
- 使用RNA测序进行转录基因分析.
- 共同培养试验和流细胞测量以评估MSC对T细胞和巨细胞的免疫抑制作用.
主要成果:
- 确定了两种MSC亚群:一种是免疫抑制的,一种是增殖的.
- 来自ACTH分泌和非功能PT的MSC抑制了T细胞的增殖,并促进了M2巨细胞的两极分化.
- 这些免疫抑制作用与编程死亡配体1,M-CSF和IL-10上调相关.
- 来自ACTH-PT的MSC表现出比非功能性PT的MSC更强的免疫抑制潜力.
结论:
- 垂体腺至少有两个不同的MSC亚群.
- MSCs的免疫抑制功能可能在垂体瘤进展中发挥重要作用.
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