[与瘤相关的巨:调节瘤微环境的新兴目标]
Yinxue Zhou1, Dunqiang Ren1, Huanhuan Bi2
1Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Zhongguo fei ai za zhi = Chinese journal of lung cancer
|April 9, 2024
概括
与瘤相关的巨细胞 (TAM) 通过创造一种免疫抑制环境来推动肺癌的进展. 抗血管生成药物显示出重编程这些前瘤TAM成抗瘤细胞的潜力,提供新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 瘤相关巨细胞 (TAM) 是肺癌免疫微环境的关键调节者.
- TAM通过表型和功能变化影响瘤的启动,进展,入侵和转移.
- 大细胞分化为M1 (抗瘤) 和M2 (前瘤) 亚型;TAM通常采用M2表型,抑制抗瘤免疫力.
结论:
- 调节TAM极化和功能为肺癌提供了新的治疗点.
- 重编程TAM为增强抗瘤免疫力和治疗结果提供了一个有希望的策略.
- 向TAM可能会克服耐药性,并提高当前肺癌疗法的有效性.
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