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Updated: Jun 29, 2025

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins
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Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

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开发一流的RIPK1降解剂来增强抗瘤免疫力

Xin Yu, Dong Lu, Xiaoli Qi

    bioRxiv : the preprint server for biology
    |April 9, 2024
    PubMed
    概括

    研究人员开发了LD4175,一种新的PROTAC降解剂,准受体相互作用蛋白激酶1 (RIPK1). 这种新分子通过触发免疫细胞死亡和使瘤对免疫检查点阻塞疗法的敏感来增强癌症免疫疗法.

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    High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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