卡尼菌 (Faecalibacterium duncaniae) 是一种新型的下一代益生菌,用于抗击流感
Loïc Chollet1, Séverine Heumel1, Lucie Deruyter1
1Univ. Lille, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Centre Hospitalier Universitaire (CHU) Lille, Institut Pasteur de Lille, U1019-Unité Mixte de Recherche (UMR) 9017 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France.
Frontiers in immunology
|April 9, 2024
概括
通过减少疾病严重程度和肺部炎症,Faecalibacterium duncaniae补充剂改善了小鼠的流感结果. 这种益生菌恢复了肠道微生物群平衡和短链脂肪酸,为病毒性呼吸道感染提供了下一代治疗的潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠肺轴在流感等病毒性呼吸道感染中起着至关重要的作用.
- 流感感染会导致肠道失调,并显著减少微生物产生的短链脂肪酸 (SCFA),特别是酸盐.
- 丁酸盐对于控制流感至关重要,这表明针对丁酸盐的基于微生物组的疗法可能是有益的.
研究的目的:
- 研究酸盐产生的细菌Faecalibacterium duncaniae对流感结果的潜在治疗作用.
- 评估F. duncaniae对肠道失调,肺病毒载荷,肺炎和二次细菌感染的影响.
主要方法:
- 在感染流感5天前,小鼠被口服活体Faecalibacterium duncaniae菌株 (A2-165或I-4574) .
- 用16S rRNA测序分析了肠道微生物组成.
- 评估了疾病的严重程度,肺病毒载荷,肺炎,SCFA水平和二次细菌感染的结果.
主要成果:
- 补充F. duncaniae导致较不严重的流感疾病,减少肺病毒载量,并减少肺炎.
- 补充剂减轻了因流感引起的肠道失调,并促进了SCFA水平的恢复,包括丁酸盐.
- 活体F. duncaniae比巴氏杀菌形式更有效,并且提供了对二次细菌感染的部分保护.
结论:
- 菌 (Faecalibacterium duncaniae) 显示出作为一种新型益生菌在治疗急性病毒性呼吸道疾病方面的巨大潜力.
- 用F. duncaniae向肠道微生物群可能是一个有希望的治疗策略,以改善流感感染期间的结果.
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